:root {
  --navy: #123056;
  --navy-deep: #0c2240;
  --blue: #275a9a;
  --ink: #1c2836;
  --muted: #3e5164;
  --paper: #f6f3ec;
  --card: #fffcf7;
  --line: #ddd4c6;
  --gold: #8d6a32;
  --white: #ffffff;
  --shadow: 0 18px 40px rgba(18, 48, 86, 0.12);
  --serif: "Iowan Old Style", Palatino, "Palatino Linotype", Georgia, serif;
  --sans: "Avenir Next", "Segoe UI", sans-serif;
}

* { box-sizing: border-box; }

html { scroll-behavior: smooth; }

body {
  margin: 0;
  color: var(--ink);
  background: var(--paper);
  font-family: var(--sans);
  font-size: 1.05rem;
  line-height: 1.6;
}

img { max-width: 100%; height: auto; display: block; }

a { color: var(--blue); }

h1, h2, h3 {
  font-family: var(--serif);
  font-weight: 600;
  line-height: 1.15;
  letter-spacing: -0.02em;
}

h1 { font-size: clamp(3.2rem, 8vw, 5.4rem); margin: 0 0 0.35em; }
h2 { font-size: clamp(2rem, 4vw, 2.8rem); margin: 0 0 0.45em; }
h3 { font-size: 1.35rem; margin: 0 0 0.4em; }

p { margin: 0 0 1em; }

.wrap {
  width: min(1120px, calc(100% - 2.4rem));
  margin: 0 auto;
}

.skip {
  position: absolute;
  left: 1rem;
  top: -4rem;
  background: var(--white);
  color: var(--navy);
  padding: 0.5rem 0.8rem;
  z-index: 10;
}

.skip:focus { top: 1rem; }

.kicker {
  margin: 0 0 0.6rem;
  color: var(--gold);
  font-size: 0.78rem;
  font-weight: 700;
  letter-spacing: 0.16em;
  text-transform: uppercase;
}

.kicker-light { color: #f0d7a4; }

.lede, .section-lead {
  font-size: 1.15rem;
  color: var(--muted);
  max-width: 42rem;
}

.site-header {
  position: sticky;
  top: 0;
  z-index: 5;
  background: var(--navy-deep);
  color: var(--white);
}

.header-inner {
  display: flex;
  align-items: center;
  justify-content: space-between;
  min-height: 4.4rem;
  gap: 1rem;
}

.brand {
  color: var(--white);
  text-decoration: none;
  font-family: var(--serif);
  font-size: 1.55rem;
  letter-spacing: -0.03em;
}

.brand span { color: #f0d7a4; }

.site-nav {
  display: flex;
  gap: 1.15rem;
}

.site-nav a {
  color: #e7eef6;
  text-decoration: none;
  font-size: 0.95rem;
}

.site-nav a:hover,
.site-nav a:focus-visible { color: #f0d7a4; }

.nav-toggle,
.nav-burger { display: none; }

.hero {
  background:
    linear-gradient(180deg, rgba(18, 48, 86, 0.94), rgba(18, 48, 86, 0.88)),
    var(--navy) url("/images/icons-bg.png");
  color: var(--white);
  padding: 4.5rem 0 3.5rem;
}

.hero .lede { color: #d5e2ef; }

.hero-grid,
.about-grid,
.product-grid,
.audience,
.steps,
.patient-grid {
  min-width: 0;
}

.hero-grid > *,
.about-grid > *,
.product-grid > *,
.audience > *,
.steps > *,
.patient-grid > * {
  min-width: 0;
}

.hero-grid {
  display: grid;
  grid-template-columns: 1.05fr 0.95fr;
  gap: 2.5rem;
  align-items: center;
}

.hero-figure img {
  width: 100%;
  border-radius: 1.1rem;
  box-shadow: var(--shadow);
  object-fit: cover;
  max-height: 420px;
}

.hero-actions {
  display: flex;
  flex-wrap: wrap;
  gap: 0.75rem;
  margin-top: 1.4rem;
}

.btn {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-height: 2.8rem;
  padding: 0.55rem 1.1rem;
  border-radius: 999px;
  text-decoration: none;
  font-weight: 600;
  border: 1px solid transparent;
}

.btn-primary {
  background: #f0d7a4;
  color: var(--navy-deep);
}

.btn-primary:hover,
.btn-primary:focus-visible { background: #fff4dc; }

.btn-ghost {
  color: var(--white);
  border-color: rgba(255, 255, 255, 0.45);
}

.btn-ghost:hover,
.btn-ghost:focus-visible { border-color: #f0d7a4; color: #f0d7a4; }

.btn-line {
  color: var(--navy);
  border-color: var(--line);
  background: var(--card);
}

.btn-line:hover,
.btn-line:focus-visible { border-color: var(--blue); }

.about, .labs, .patients { padding: 4.5rem 0; }

.about { background: var(--paper); }

.about-grid {
  display: grid;
  grid-template-columns: 1.2fr 0.8fr;
  gap: 2.5rem;
  align-items: start;
}

.facts {
  list-style: none;
  margin: 0;
  padding: 0;
  display: grid;
  gap: 0.8rem;
}

.facts li {
  background: var(--card);
  border: 1px solid var(--line);
  border-radius: 0.9rem;
  padding: 1rem 1.1rem;
}

.facts strong {
  display: block;
  font-family: var(--serif);
  font-size: 1.35rem;
  color: var(--navy);
}

.facts span { color: var(--muted); font-size: 0.95rem; }

.product {
  background:
    linear-gradient(180deg, rgba(39, 90, 154, 0.94), rgba(18, 48, 86, 0.96)),
    var(--blue) url("/images/icons-bg.png");
  color: var(--white);
  padding: 4.5rem 0;
}

.product p { color: #e4edf6; }

.product-head {
  display: flex;
  gap: 1.4rem;
  align-items: center;
  margin-bottom: 2rem;
}

.product-logo {
  width: 180px;
  background: var(--navy-deep);
  border-radius: 0.7rem;
  padding: 0.7rem 0.85rem;
}

.product-grid {
  display: grid;
  grid-template-columns: 1.15fr 0.85fr;
  gap: 2rem;
  align-items: center;
}

.collage img { margin: 0 auto; width: min(100%, 380px); }

.audience {
  list-style: none;
  margin: 2.4rem 0 0;
  padding: 0;
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 1rem;
}

.audience li {
  background: rgba(255, 255, 255, 0.08);
  border: 1px solid rgba(255, 255, 255, 0.16);
  border-radius: 0.9rem;
  padding: 1.15rem 1.15rem 1.2rem;
}

.audience h3 { color: var(--white); }

.audience a {
  color: #f0d7a4;
  font-weight: 700;
  text-decoration: none;
}

.audience a:hover,
.audience a:focus-visible { text-decoration: underline; }

.labs { background: #fffdf9; }

.steps {
  list-style: none;
  margin: 2rem 0 0;
  padding: 0;
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 1rem;
  counter-reset: step;
}

.steps li {
  background: var(--card);
  border: 1px solid var(--line);
  border-radius: 0.9rem;
  padding: 1.2rem 1.2rem 0.4rem 1.2rem;
  counter-increment: step;
}

.steps h3::before {
  content: counter(step);
  display: inline-grid;
  place-items: center;
  width: 1.7rem;
  height: 1.7rem;
  margin-right: 0.55rem;
  border-radius: 50%;
  background: var(--navy);
  color: var(--white);
  font-family: var(--sans);
  font-size: 0.85rem;
  vertical-align: 0.1rem;
}

.callout {
  margin-top: 1.6rem;
  padding: 1.3rem 1.3rem 1.4rem;
  border-left: 4px solid var(--gold);
  background: var(--paper);
  border-radius: 0 0.8rem 0.8rem 0;
}

.patients { background: var(--paper); }

.patient-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 1rem;
  margin: 1.6rem 0 0.4rem;
}

.patient-grid article {
  background: var(--card);
  border: 1px solid var(--line);
  border-radius: 0.9rem;
  padding: 1.15rem 1.2rem 0.3rem;
}

.note {
  color: var(--muted);
  margin-top: 1.2rem;
}

.contact {
  background:
    linear-gradient(180deg, rgba(12, 34, 64, 0.92), rgba(12, 34, 64, 0.94)),
    var(--navy-deep) url("/images/icons-bg.png");
  color: var(--white);
  padding: 4.5rem 0;
}

.contact p { color: #d5e2ef; max-width: 36rem; }

.contact-inner {
  display: flex;
  justify-content: space-between;
  align-items: flex-end;
  gap: 2rem;
}

.contact h2 { margin-bottom: 0.4em; }

.contact-email {
  display: inline-block;
  color: var(--navy-deep);
  background: #f0d7a4;
  text-decoration: none;
  font-family: var(--serif);
  font-size: clamp(1.4rem, 3vw, 2rem);
  padding: 0.85rem 1.15rem;
  border-radius: 0.8rem;
  line-height: 1.2;
}

.contact-email:hover,
.contact-email:focus-visible { background: #fff4dc; }

.site-footer {
  background: #08182c;
  color: #c5d3e2;
  padding: 1.2rem 0;
  font-size: 0.95rem;
}

.footer-inner {
  display: flex;
  justify-content: space-between;
  gap: 1rem;
}

.site-footer a { color: #f0d7a4; }

.site-footer p { margin: 0; }

.missing {
  padding: 5rem 0 6rem;
}

.missing .btn-line { color: var(--navy); }

@media (max-width: 860px) {
  .hero-grid,
  .about-grid,
  .product-grid,
  .audience,
  .steps,
  .patient-grid,
  .contact-inner,
  .footer-inner {
    grid-template-columns: 1fr;
    display: grid;
  }

  .contact-inner,
  .footer-inner { display: grid; }

  .product-head { align-items: flex-start; flex-direction: column; }

  .nav-burger {
    display: grid;
    place-items: center;
    width: 2.6rem;
    height: 2.6rem;
    border: 1px solid rgba(255, 255, 255, 0.3);
    border-radius: 0.45rem;
    cursor: pointer;
  }

  .nav-burger span,
  .nav-burger span::before,
  .nav-burger span::after {
    display: block;
    width: 1.1rem;
    height: 2px;
    background: var(--white);
    position: relative;
    content: "";
  }

  .nav-burger span::before { position: absolute; top: -6px; }
  .nav-burger span::after { position: absolute; top: 6px; }

  .site-nav {
    display: none;
    position: absolute;
    left: 0;
    right: 0;
    top: 4.4rem;
    background: var(--navy-deep);
    padding: 0.4rem 1.2rem 1rem;
    flex-direction: column;
    border-bottom: 1px solid rgba(255, 255, 255, 0.12);
  }

  .nav-toggle:checked ~ .site-nav { display: flex; }

  .site-nav a { padding: 0.45rem 0; }
}